If you're taking MacuDopa (a natural levodopa supplement derived from Mucuna pruriens), it's important to time your protein intake wisely. This is because levodopa and dietary protein compete for absorption in the gut and transport across the blood-brain barrier, potentially reducing the effectiveness of your medication.
Levodopa is absorbed in the small intestine using the same transport system as large neutral amino acids (LNAAs) found in protein-rich foods like meat, eggs, and dairy. When you eat a large protein meal around the same time as MacuDopa, these amino acids can block or delay levodopa absorption, leading to weaker symptom relief or unpredictable "off" periods.
Instead of consuming high-protein meals with your dose, try taking MacuDopa on an empty stomach or with a small low-protein snack. If you require more protein, consider shifting it to your evening meal when the impact on MacuDopa’s effectiveness is minimal.
By managing your daily protein intake, you can maximise levodopa absorption and improve symptom control, helping you maintain better movement and energy levels throughout the day.